Depletion of lncRNA MEG3 Ameliorates Imatinib-Induced Injury of Cardiomyocytes via Regulating miR-129-5p/HMGB1 Axis

Figure 1

MEG3 is highly expressed in imatinib-induced cardiomyocyte in hypoxic condition. (a) Chemical structure of imatinib. (b) H9c2 cells were pretreated with imatinib followed by hypoxia induction, and the viability of each group of cells was subsequently measured using a CCK-8 assay. (c and d) H9c2 cells were pretreated with imatinib followed by hypoxia induction, followed by TUNEL assay and flow cytometry to detect apoptosis in each group of cells. (e) Western blot was performed to detect the expression levels of caspase 3 and cleaved caspase 3 in H9c2 cells of each group. , , and .

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