Depletion of lncRNA MEG3 Ameliorates Imatinib-Induced Injury of Cardiomyocytes via Regulating miR-129-5p/HMGB1 Axis

Figure 4

MEG3 is involved in imatinib-induced myocardial injury by targeting miR-129-5p. (a) si-MEG3#2 and miR-129-5p inhibitors were cotransfected into H9c2 cells, followed by imatinib treatment, then hypoxia induction, and finally qRT-PCR was performed to detect miR-129-5p expression. (b) A CCK-8 assay was performed to detect the cell viability of H9c2 cells in each group. (c) A TUNEL assay was executed to detect apoptosis of H9c2 cells in each group. (d) The apoptosis of H9c2 cells was detected by flow cytometry. .

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