Intraoperative Touch Imprint Cytology of Brain Neoplasms: A Useful High-Diagnostic Tool in 93 Consecutive Cases; Differential Diagnoses, Pitfalls, and Traps

Figure 1

Glioblastoma. (a, b) If only necrosis is detected in an intraoperative evaluation, which is defined as a nonspecific pattern in touch imprint cytology, the surgeon is requested to send a shallower specimen with a high probability of containing viable tumor cells for correct classification (H&E, ×40, ×400). With the resampling by the surgeon, (c, d) touch imprint cytology, and (e, f) histopathological sections show marked atypia, microvascular proliferation, mitotic figures, pseudopalisating necrosis, and cellular pleomorphism (H&E, ×40, ×100, ×400).