Intraoperative Touch Imprint Cytology of Brain Neoplasms: A Useful High-Diagnostic Tool in 93 Consecutive Cases; Differential Diagnoses, Pitfalls, and Traps

Figure 9

Embryonal tumors of the central nervous system. (a, b) Medulloblastoma: tumor cells are observed in groups containing hyperchromatic nuclei with minimal cytoplasm (H&E, ×100, ×400). Embryonal tumor with multilayered rosettes (ETMR). (c) In touch imprint cytology and (d) ETMRs can be used to replicate the same blast cells in multiples, biphasic histopathological pattern in low magnification; neuropil-rich areas and rosette formation are observed (H&E, ×40, ×400). (e) At higher magnification, rosettes are multilayered (H&E, ×400). (f) LIN28A has been identified as a diagnostic marker for ETMRs. ETMRs were diffuse and intensely positive in their multilayered rosettes and small blue and round cells.