Astragaloside IV Protects against Shear Stress-Induced Glycocalyx Damage and Alleviates Abdominal Aortic Aneurysm by Regulating miR-17-3p/Syndecan-1

Figure 3

AS-IV inhibits miR-17-3p expression in endothelial cells of AAA rats. (a) The heat map shows different miRNAs in the peripheral blood of healthy individuals, untreated patients with AAA, and treated patients with AAA. (b) FISH was used to detect miR-17-3p expression in the abdominal aorta. (c) RT-qPCR was used to detect miR-17-3p expression in the abdominal aorta. vs. Sham group; ^### vs. AAA group; ^^^ vs. AAA + AS-IV-40 group. AS-IV, astragaloside IV; AAA, abdominal aortic aneurysm; FISH, fluorescence in situ hybridization; and RT-qPCR, real-time quantitative reverse transcription PCR.

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