Astragaloside IV Protects against Shear Stress-Induced Glycocalyx Damage and Alleviates Abdominal Aortic Aneurysm by Regulating miR-17-3p/Syndecan-1

Figure 5

AS-IV inhibits miR-17-3p expression and promotes SDC1 expression in HAECs. (a) The impact of shear stress on miR-17-3p expression in HAECs. (b–d) The impact of shear stress on SDC1 mRNA and protein expression in HAECs. (e) The impact of different AS-IV concentrations on cell viability of HAECs. (f) The impact of AS-IV on miR-17-3p expression in HAECs. (g–i) The impact of AS-IV on SDC1 mRNA and protein expression in HAECs. , , vs. 0 dyn/cm² shear stress group or 0 μmol/L AS-IV group. AS-IV, astragaloside IV; AAA, abdominal aortic aneurysm; SDC1, syndecan-1; and HAECs, human aortic endothelial cells.

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