Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases

Table 1

Characteristics of different PLD subtypes.

	PX/PH domains	Base numbers	Intracellular localization	Isoform-specific tissue expression	References
PLD1	Exist	1,074	Perinuclear vesicular localization, plasma membrane	Heart, brain, pancreas, uterus, and intestine	[16]
PLD2	Exist	933	Plasma membrane	Brain, placenta, lung, thymus, prostate, and uterine tissue	[17]
PLD3	Null	490	The luminal side of the endoplasmic reticulum	Brain, smooth muscle, skeletal muscle, heart muscle, lung tissue, and epididymis	[18]
PLD4	Null	506	Endoplasmic reticulum and golgi apparatus	Liver, spleen, brain, and lymph nodes	[19]
PLD5	Null	506	Endoplasmic reticulum and golgi apparatus	Liver, spleen, brain, and lymph nodes	[15]
PLD6	Null	252	The outer surface of the mitochondria	Adrenal glands and gonads	[20]

PLD, phospholipase D.