| | PX/PH domains | Base numbers | Intracellular localization | Isoform-specific tissue expression | References |
| PLD1 | Exist | 1,074 | Perinuclear vesicular localization, plasma membrane | Heart, brain, pancreas, uterus, and intestine | [16] | PLD2 | Exist | 933 | Plasma membrane | Brain, placenta, lung, thymus, prostate, and uterine tissue | [17] | PLD3 | Null | 490 | The luminal side of the endoplasmic reticulum | Brain, smooth muscle, skeletal muscle, heart muscle, lung tissue, and epididymis | [18] | PLD4 | Null | 506 | Endoplasmic reticulum and golgi apparatus | Liver, spleen, brain, and lymph nodes | [19] | PLD5 | Null | 506 | Endoplasmic reticulum and golgi apparatus | Liver, spleen, brain, and lymph nodes | [15] | PLD6 | Null | 252 | The outer surface of the mitochondria | Adrenal glands and gonads | [20] |
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