Advances in Medicine

Review Article

Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Table 1

Important antimalarial drugs and their developmental stages.
AntimalarialYear of developmentDevelopmental phase
Quinine1820In clinical use
Chloroquine1934In clinical use
Proguanil1945In clinical use
Pyrimethamine1952In clinical use
Piperaquine1966In clinical use
Lumefantrine1967In clinical use
Pyronaridine1967In clinical use
Mefloquine1974In clinical use
Sulphadoxine1981In clinical use
Artemisinin1972In clinical use
Atovaquone1991In clinical use
ArtefenomelUnder developmentPhase 1
DSM265Under developmentPhase 1
M5717Under developmentPhase 1
MeplazumabUnder developmentPhase 1
MMV688533Under developmentPhase 1
SAR441121Under developmentPhase 1
ZY-19489Under developmentPhase 1
CipargaminUnder developmentPhase 2
DM1157Under developmentPhase 2
MMV390048Under developmentPhase 2
SJ733Under developmentPhase 2
TafenoquineUnder developmentPhase 2
5-ALA HCl with SFCUnder developmentPhase 2
Artefenomel-ferroquineUnder developmentPhase 2
Imatinib-DHA-piperaquineUnder developmentPhase 2
Methylene blue with artemether and lumefantrineUnder developmentPhase 2
Ganaplacide with LUM-SDFUnder developmentPhase 3
Artemether-lumefantrineUnder developmentPhase 4