New Tin (IV) and Organotin (IV) Complexes with a Hybrid Thiosemicarbazone/Hydrazone Ligand: Synthesis, Crystal Structure, and Antiproliferative Activity

Figure 8

Concentration-dependent increase in intracellular ROS accumulation of MDA-MB-231 cells, in response to treatment with complex 3. Post treatment with 3 (0.25 µM, 0.5 µM, and 1 µM) for 24 h, cells were stained with H₂DCFDA. (a) showing fluorescence microscopic analysis, (a) and (b) showing fold increase in fluorescence intensity, and (c) showing FACS analysis, where X axis denotes cell count where each experimental condition has normalized cell population of 200. (c) and (d) showing fold change in mean fluorescence intensity. The level of significance was set at ; ; and in respect to the control.

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