BioMed Research International / 2021 / Article / Tab 1 / Research Article
Pooled Analysis of the Accuracy of Xpert Ebola Assay for Diagnosing Ebola Virus Infection Table 1 Characteristics of the included 4 studies.
Authors Study design Location Source of strains Reference standard Ebola virus Blinded review or interpretation The characteristics of the controls TP FP FN TN James Pettitt [19 ] (2015) Prospective cohort study America 402 semen Ebola Zaire target 1 (EZ1) and major groove binder RT-PCR 94 0 4 308 Yes Samples were collected from uninfected individuals Amy James Loftis [20 ] (2016) Prospective cohort study America 80 semen Traditional PCR 30 0 0 50 Yes Samples were procured commercially from healthy donors Rafael Van den Bergh [14 ] (2016) Prospective cohort study Belgium 218 semen A routine in-house Ebola PCR 18 8 0 192 Yes Suspected EVD patients for routine diagnosis between May 2 and July 4, 2015 Amanda E. Semper [15 ] (2016) Prospective cohort study England 218 WB Reverse transcription PCR, Trombley 22 8 0 181 Yes Residual diagnostic specimens remaining after clinical testing from suspected or confirmed EVD patients between April 1 and July 20, 2015 Amanda E. Semper [15 ] (2016) Prospective cohort study England 64 semen Reverse transcription PCR, Trombley 20 0 0 44 Yes Residual diagnostic samples remaining after clinical testing from suspected or confirmed EVD patients between March 7 and July 20, 2015, some of which had been frozen before use
TP: true positive; TN: true negative; FP: false positive; FN: false negative; WB: whole blood.