Review Article
Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis
Table 2
Results of subgroup analysis.
| Outcome indicators | Number of included studies | Sample size | Heterogeneity | Effect of model | Meta-analysis results | values | I2 | t2 (%) | R% (95% CI) |
| Gastrointestinal symptoms | US | 21 | 1208 | <0.01 | 72.80 | 0.015 | Random | 87.77% (85.86%–89.55%) | Europe | 21 | 753 | <0.01 | 79.90 | 0.0325 | Random | 76.53% (73.44%–79.48%) | Other countries | 9 | 165 | <0.01 | 61.60 | 0.0231 | Random | 70.54% (63.38%–77.23%) | N < 50 | 44 | 757 | <0.03 | 70.10 | 0.0345 | Random | 84.11% (78.68%–88.87%) | N ≥ 50 | 7 | 1369 | <0.04 | 94.30 | 0.0243 | Random | 78.46% (67.80%–87.46%) |
| Respiratory symptoms | US | 17 | 1128 | <0.01 | 88.60 | 0.0393 | Random | 47.68% (36.53%–58.94%) | Europe | 12 | 489 | <0.01 | 84.90 | 0.0503 | Random | 53.77% (38.615–68.59%) | Other countries | 7 | 136 | <0.01 | 84.60 | 0.0354 | Random | 67.01% (44.77%–85.83%) | N < 50 | 30 | 500 | <0.01 | 81.30 | 0.0667 | Random | 54.98% (44.15%–65.57%) | N ≥ 50 | 6 | 1253 | <0.01 | 94.40 | 0.0236 | Random | 50.63% (37.88%–63.33%) |
| Lymphocytopenia | US | 13 | 1206 | <0.01 | 93.08 | 0.0729 | Random | 58.70% (41.92%–74.50%) | Europe | 7 | 77 | <0.01 | 70.90 | 0.0629 | Random | 84.01% (63.93%–96.84%) | Other countries | 8 | 134 | <0.01 | 40.70 | 0.0112 | Fixed | 48.96% (40.55%–57.40%) | N < 50 | 25 | 351 | <0.01 | 77.40 | 0.0627 | Random | 62.05% (50.28%–73.14%) | N ≥ 50 | 3 | 855 | <0.01 | 98.40 | 0.0718 | Random | 58.4% (28.61%–85.23%) |
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