Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells

<div>Valsartan prevented Hcy-induced impaired autophagy and ERs in HUVECs. (a, b) Representative immunoblots and corresponding densitometry analysis of LC3B, Beclin1, and p62 protein in Hcy-treated HUVECs pretreated with or without valsartan. (c) Immunofluorescence of LC3B in Hcy-treated HUVECs pretreated with valsartan. Scale bars, 5 <i>μ</i>m. (d, e) Representative immunoblots and corresponding densitometry analysis of BiP, IRE1<i>α</i>, XBP1, ATF4, and CHOP protein in Hcy-treated HUVECs with or without valsartan. 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Cardiovascular Therapeutics

fig2

Figure 2

Figure 2: Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells 