Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway

Figure 8

Molecular mechanism involved in vascular remodeling. Vessel injury as in the case of PCI causes Tgfβ1, activates Smad2/3 phosphorylation, and contributes to the transcription of genes taken part in vascular remodeling. Ginkgolide B represses the production of Tgfβ1, further reduces Smad2/3 phosphorylation, and contributes to the decline transcription of genes taken part in vascular remodeling, which could decrease restenosis and thrombosis.