Role of K⁺ and Ca²⁺ Channels in the Vasodilator Effects of Plectranthus barbatus (Brazilian Boldo) in Hypertensive Rats

Table 1

Annotated compounds from the hydroethanolic extract of P. barbatus (HEPB).

Peak	RT (min)	MF	UV (nm)	Negative ion mode (m/z)		Positive ion mode (m/z)		Compound
				MS [M-H]^-	MS/MS	MS [M+H]^+	MS/MS
1	1.1	C6H8O7	—	191.0202	—	215.0163^Na	—	Citric acid
2	3.7	C9H10O5	281	197.0461	179, 151	221.0427^Na	—	Syringic acid
3	7.7	C14H20O7	—	299.1146	—	323.1106^Na	279, 246, 204, 189	Unknown
4	15.3	C13H12O7	299, 313	279.0529	163	303.0473^Na	—	p-Coumaroyl malate
5	18.7	C22H22O12	270, 347	477.1053	314, 299, 285, 271, 255, 171	479.1189	317, 302, 191	O-Hexosyl O-methyl quercetin
6	18.9	C21H18O12	268, 348	461.0737	285, 257, 241, 175, 151	463.0872	287	O-Glucuronyl kaempferol
7	20.3	C22H30O8	—	421.1870	325, 308, 267, 195, 163	445.1845^Na	385, 367, 309, 225	Unknown
8	21.2	C18H16O8	299, 328	359.0792	197, 179, 161	361.0916	—	Rosmarinic acid
9	23.9	C16H12O7	282, 342	315.0521	300, 271, 243, 202	317.0660	302, 274, 168	O-Methyl quercetin
10	24.4	C19H32O10	286, 334	421.2082	317	445.2057	333, 275, 229	Unknown
11	24.8	C11H12O4	299, 325	207.0671	179, 161	209.0809	163	Di-O-methyl caffeic acid
12	25.7	C15H10O6	268, 342	285.0410	257, 243, 225, 217, 183, 175	287.0557	269, 241, 153	Luteolin
13	27.6	C24H32O9	—	463.1985	—	465.2129	299, 281, 263, 239, 211, 160, 149	Cyclobutatusin
14	28.75	C22H20O12	286, 334	475.0884	299, 284	477.1053	301, 203, 167	O-Glucuronyl O-methyl scutellarein
15	29.0	C15H10O5	266, 336	269.0450	227, 202, 182, 171, 151	271.0597	243, 229, 201, 187, 169, 153	Apigenin
16	30.4	C31H32O11	330	579.1878	519, 475, 420, 395, 376, 323	581.2026	521, 203, 485, 411 393, 375, 367, 323, 309	Unknown
17	32.9	C22H28O8	280	419.1716	359, 331, 315, 272	421.1853	343, 325, 301, 273, 245, 219	Diterpenoid (coleon H)
18	35.4	C22H32O5	—	375.2180	313, 271, 259, 219	377.2313	299, 271, 217, 175, 161, 149	Unknown
19	37.1	C27H46O9	—	513.3078	317, 277, 209	515.3220	335, 261, 243, 187	Unknown

RT: retention time; MF: molecular formula. ^Na[M+Na]⁺.