Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Compounds</td><td class="align_center">Model</td><td class="align_center">EMT-related target</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">miR-124-3p [<a href="/journals/crj/2023/3291957/#B81" target="_blank">81</a>]</td><td class="align_center">Asthmatic mouse models</td><td class="align_center">TGF-<i>β</i>/Smad2</td></tr><tr><td class="align_left">miR-506 [<a href="/journals/crj/2023/3291957/#B82" target="_blank">82</a>]</td><td class="align_center">TGF-<i>β</i>1-induced ASMCs cells</td><td class="align_center">Wnt/<i>β</i>-catenin</td></tr><tr><td class="align_left">Vitamin D [<a href="/journals/crj/2023/3291957/#B83" target="_blank">83</a>]</td><td class="align_center">Calcitriol, beclomethasone 17-propionate, montelukast sodium, LTD4 and TGF-<i>β</i>-induced HFL1 cells</td><td class="align_center">Vimentin, TGF</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Specific microRNAs or vitamins involved in EMT in different respiratory symptoms.</div>

Canadian Respiratory Journal

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Table 4

Table 4: Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression 