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| Authors | Year | Location | Purpose | Type of source | Summary points |
|
| Behan et al. [28] | 2008 | UK | Comparing general anesthesia and conscious sedation in TAVR procedures | Prospective cohort study | (i) No statistical difference in ICU transfer, procedure duration, and hospital stay between groups |
|
| Dehédin et al. [29] | 2011 | France | Comparing general anesthesia and local/regional anesthesia in TAVR procedures | Retrospective cohort study | (i) Incidence of hemodynamic instability and blood pressure required maintenance lower in the local anesthesia group |
| (ii) No difference in procedural success and mortality rates in both groups |
|
| Ben-Doret al. [30] | 2012 | USA | Comparing monitored anesthesia care and general anesthesia in TAVR procedures | Prospective cohort study | (i) Procedure duration was significantly shorter for the MAC group |
| (ii) Median intensive care unit and hospital stays were lower in the MAC group |
| (iii) There was no significant difference in procedural complications between the groups |
| (iv) Rise in creatinine was higher in the general anesthesia group |
|
| Motloch et al. [31] | 2012 | Austria | Comparing local anesthesia and general anesthesia in TAVR procedures | Retrospective cohort study | (i) Hemodynamic parameters were statistically more stable in the local anesthesia group |
| (ii) Procedural time was significantly lower in the local anesthesia group |
| (iii) Peak-systolic central aortic pressure and mean central aortic pressure were significantly higher in the local anesthesia group |
| (iv) The need for adrenergic support during intervention was significantly lower in the local anesthesia group |
|
| Yamamoto et al. [25] | 2013 | France | Comparing general anesthesia and conscious sedation in TAVR procedures | Prospective cohort study | (i) No significant difference in procedural complications was seen between the groups |
| (ii) The ejection fraction was significantly lower in the general anesthesia group |
| (iii) The mortality predictive score was significantly higher in the general anesthesia group |
| (iv) Total procedure time, length of hospital stay, and length of intensive care unit stay were significantly longer in the general anesthesia group |
|
| Oguri et al. [24] | 2014 | France | Comparing general and local anesthesia in TAVR procedures | Retrospective cohort study | (i) Cumulative 30-day mortality rates were significantly higher in the general anesthesia group, but no significant difference with propensity matching between the groups |
| (ii) Hospital duration was significantly higher in the local anesthesia group |
| (iii) No significant difference in postoperative complications between the groups |
|
| Mayr et al. [18] | 2016 | Germany | Comparing sedation and general anesthesia in TAVR procedures | Single-center, controlled, parallel-groupstudy with balanced randomization (1 : 1) | (i) No statistical difference in cerebral oxygenation or neurocognitive outcome |
| (ii) Incidence of adverse events, specifically pain and respiratory depression were higher in the sedation group |
|
| Gurevich et al. [22] | 2017 | USA | Comparing minimalist approach to the standard TAVR procedure | Retrospective cohort study | (i) A minimalist approach was associated with improved procedural efficiency and reduced hospital length of stay |
| (ii) No statistical differences in procedural or clinical outcomes was noted between the groups |
|
| Husser et al. [23] | 2017 | USA/Europe | Comparing general anesthesia and conscious sedation in TAVR procedures | Retrospective cohort study | (i) Fewer postprocedural outcomes were reported in the conscious sedation group |
|
| Butala et al. [15] | 2020 | USA | Comparing general anesthesia and conscious sedation in TAVR procedures | Retrospective cohort study | (i) Conscious sedation was associated with a decrease in in-hospital mortality, lower 30-day mortality, less use of inotropic drugs, shorter length of hospital stay, and more frequent discharges |
|
| Thiele et al. [10] | 2020 | Europe | Comparing general anesthesia and conscious sedation in TAVR procedures | Randomized clinical trial | (i) There was no statistical difference in all-cause mortality, stroke, myocardial infarction, infection requiring antibiotic treatment, and acute kidney injury between the groups |
| (ii) No statistical differences in the median length of ICU and hospital stay were noted between groups |
| (iii) There was no significant difference in device time, total procedural time, occurrence of delirium, moderate or severe prosthetic valve regurgitation at 30 days, ICU stay, hospital stay, and cardiovascular mortality between the groups |
| (iv) The need and dose of vasopressors and inotropes were statistically higher in the general anesthesia group |
|
| Musuku et al. [19] | 2021 | USA | Comparing general anesthesia using a subglottic airway and monitored anesthesia care in TAVR procedures | Retrospective cohort study | (i) There was no significant difference between general anesthesia using subglottic airway and monitored anesthesia care in morbidity, 30-day mortality, and hospital or postanesthesia care unit length of stay |
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