Body Weight Variability and Risk of Suicide Mortality: A Nationwide Population-Based Study

Table 3

The risk of suicide according to the quartiles of body weight variability (VIM) in subgroups by sex, age, diabetes, and depression.

		Events	Incidence rate	HR (95% CI)	Adjusted HR (95% CI)^#
Sex
Male
Q1	317761	1121	0.32	1 (reference)	1 (reference)
Q2	319121	1111	0.31	0.99 (0.91-1.07)	1.01 (0.93-1.10)
Q3	314771	1228	0.35	1.11 (1.02-1.20)	1.13 (1.04-1.23)
Q4	289367	1354	0.43	1.35 (1.25-1.46)	1.35 (1.24-1.46)
Female
Q1	177592	226	0.11	1 (reference)	1 (reference)
Q2	177711	229	0.12	1.01 (0.84-1.22)	1.02 (0.85-1.23)
Q3	180824	245	0.12	1.07 (0.89-1.28)	1.06 (0.89-1.28)
Q4	206554	369	0.16	1.42 (1.20-1.68)	1.37 (1.16-1.62)
for interaction				0.790	0.842
Age
20-39 years
Q1	129241	247	0.17	1 (reference)	1 (reference)
Q2	146774	299	0.18	1.07 (0.90-1.26)	1.07 (0.90-1.26)
Q3	164735	340	0.18	1.08 (0.92-1.27)	1.10 (0.93-1.29)
Q4	200734	434	0.19	1.13 (0.97-1.33)	1.30 (1.11-1.52)
40-64 years
Q1	305882	753	0.22	1 (reference)	1 (reference)
Q2	296387	750	0.23	1.03 (0.93-1.14)	1.02 (0.92-1.13)
Q3	274631	789	0.26	1.17 (1.06-1.29)	1.16 (1.05-1.28)
Q4	225361	784	0.31	1.43 (1.29-1.58)	1.40 (1.26-1.54)
≥65 years
Q1	60230	347	0.55	1 (reference	1 (reference)
Q2	53671	291	0.52	0.95 (0.81-1.11)	0.94 (0.80-1.09)
Q3	56229	344	0.60	1.08 (0.93-1.26)	1.03 (0.89-1.20)
Q4	69826	505	0.74	1.35 (1.17-1.54)	1.22 (1.06-1.40)
for interaction				0.053	0.657
Diabetes
No
Q1	454643	1156	0.23	1 (reference)	1 (reference)
Q2	457928	1158	0.23	1.00 (0.92-1.08)	1.01 (0.93-1.10)
Q3	455765	1303	0.26	1.13 (1.04-1.22)	1.15 (1.07-1.25)
Q4	451886	1498	0.30	1.32 (1.22-1.42)	1.40 (1.29-1.51)
Yes
Q1	40710	191	0.43	1 (reference)	1 (reference)
Q2	38904	182	0.43	1.00 (0.81-1.22)	1.01 (0.82-1.24)
Q3	39830	170	0.40	0.92 (0.75-1.13)	0.92 (0.75-1.13)
Q4	44035	225	0.49	1.13 (0.93-1.37)	1.10 (0.90-1.33)
for interaction				0.143	0.027
Depression
No
Q1	483336	1272	0.24	1 (reference)	1 (reference)
Q2	484797	1247	0.23	0.98 (0.90-1.06)	1.00 (0.92-1.08)
Q3	482161	1349	0.25	1.07 (0.99-1.15)	1.10 (1.02-1.19)
Q4	478590	1528	0.29	1.23 (1.14-1.32)	1.33 (1.24-1.43)
Yes
Q1	12017	75	0.57	1 (reference)	1 (reference)
Q2	12035	93	0.71	1.24 (0.91-1.68)	1.23 (0.91-1.67)
Q3	13434	124	0.85	1.49 (1.12-1.98)	1.44 (1.08-1.91)
Q4	17331	195	1.07	1.87 (1.44-2.44)	1.68 (1.28-2.19)
for interaction				0.024	0.321

Per 1000 person-years. ^#Adjusted for age, sex, income, smoking, drinking, regular exercise, diabetes, hypertension, dyslipidemia, chronic kidney disease, depression, bipolar disease, schizophrenia, anxiety, insomnia, and body mass index. CI: confidence interval; VIM: variability independent of the mean.