Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets

Table 1

Articles included in the systematic review of cutaneous T-cell lymphoma and microbiota.

#	Authors	Title	Main findings
17	Zhang et al.	TCL-036: Alternations in the Skin Microbiota Are Associated with Symptom Severity in Mycosis Fungoides	Skin microbiota alterations are linked to symptom severity in mycosis fungoides
16	Dehner et al.	Skin Microbiota as Antigenic Triggers for Cutaneous T Cell Lymphoma	Skin microbiota may act as antigenic triggers for CTCL
14	Salava et al.	Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing	Investigated skin microbiome in CTCL using 16S and whole-genome shotgun sequencing
15	Harkins et al.	Cutaneous T-Cell Lymphoma Skin Microbiome Characterized by Shifts in Certain Commensal Bacteria	CTCL skin microbiome shows shifts in certain commensal bacteria compared to healthy controls
10	Lewis	Cutaneous microbiota in the pathogenesis of cutaneous T-cell lymphoma and role of antibiotic therapy	Explores the role of cutaneous microbiota and antibiotic therapy in CTCL pathogenesis
19	Hooper et al.	Skin microbiome in cutaneous T-cell lymphoma associated with phototherapy treatment response	Skin microbiome in CTCL is linked to phototherapy treatment response
25	Wu & Hwang	A Microbiota-Dependent, STAT3-Driven Mouse Model of Cutaneous T-Cell Lymphoma	Describes a microbiota-dependent, STAT3-driven mouse model of CTCL
37	Fanok et al.	Analysis of molecular etiology and bacterial triggers of cutaneous T-cell lymphoma	Investigates molecular etiology and bacterial triggers of CTCL
6	Kadin et al.	Evidence linking atopy and staphylococcal superantigens to lymphomatoid papulosis pathogenesis	Links atopy and staphylococcal superantigens to lymphomatoid papulosis pathogenesis
9	Hooper et al.	Gut dysbiosis in CTCL characterized by shifts in bacterial taxa and decreased diversity	Gut dysbiosis in CTCL shows shifts in bacterial taxa and decreased diversity in advanced disease
7	Emge et al.	MRSA is an important pathogen in erythrodermic CTCL patients	MRSA plays a significant role in erythrodermic CTCL patients
8	Fujii	Pathogenesis of cutaneous T-cell lymphoma: Involvement of Staphylococcus aureus	Staphylococcus aureus involvement in CTCL pathogenesis
20	Fanok et al.	Role of Dysregulated Cytokine Signaling and Bacterial Triggers in CTCL Pathogenesis	Dysregulated cytokine signaling and bacterial triggers play a role in CTCL pathogenesis
21	Krejsgaard et al.	Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation	Staphylococcal enterotoxins contribute to lymphoma-associated immune dysregulation
22	Blümel et al.	Staphylococcus aureusalpha-toxin inhibits CD8 (+) T-cell-mediated killing of cancer cells in CTCL	S. aureusalpha-toxin hinders CD8 (+) T-cell-mediated killing of cancer cells in CTCL
27	Lindahl et al.	Staphylococcus aureus and Antibiotics in Cutaneous T-Cell Lymphoma	S. aureus and antibiotics’ role in CTCL
23	Willerslev-Olsen et al.	Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T-cells in Sézary syndrome	S. aureus enterotoxins induce FOXP3 expression in neoplastic T-cells in Sézary syndrome
24	Willerslev-Olsen et al.	Staphylococcus aureus Induces STAT5-Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma	S. aureus induces STAT5-dependent miR-155 expression in CTCL
11	Lewis et al.	The “Duvic Regimen” for Erythrodermic Flares Secondary to Staphylococcus aureus in Mycosis Fungoides	Describes the “Duvic Regimen” for treating erythrodermic flares caused by S. aureus in mycosis fungoides
26	Willerslev-Olsen et al.	Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in CTCL	SEA activates STAT3 and induces IL-17 expression in CTCL
12	Lindahl et al.	Antibiotics inhibit tumor activity and disease in cutaneous T-cell lymphoma	Antibiotics inhibit tumor activity and disease progression in CTCL