Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control

Figure 2

Effect of boldine on the lactate gluconeogenesis in the perfused liver isolated from fasted rats. Time courses (a) and concentration-dependent effects of boldine (b) on lactate gluconeogenesis and related parameters in the livers isolated from fasted rats. Liver was perfused as described in the Materials and Methods. In (a), data are the of 3 to 4 liver perfusion experiments. Boxes near the time scale indicate the lactate and boldine infusion periods and concentrations. In (b), the rates of pyruvate and glucose productions and oxygen uptake were evaluated at 36 minutes of perfusion time (control condition, zero boldine concentration; ) and at 56 min perfusion time (20 minutes after starting boldine infusion; ). Asterisks () in (b) indicate those rates that differ from the control condition (absence of boldine; ).

(a)

(b)