Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control

Figure 4

Effect of boldine on glycerol gluconeogenesis in the perfused livers isolated from fasted rats. (a) The time courses of the effects of glycerol and 200 μM boldine and (b) the concentration dependences of the effects of boldine. Livers were perfused as described in the Materials and Methods. In (a), data are the of 3 to 4 liver perfusion experiments. Boxes near to the time scale indicate the glycerol and boldine infusion periods and concentrations. In (b), the rates of pyruvate, lactate, and glucose productions and oxygen uptake were evaluated at 36 minutes of perfusion time (control condition; ) and at 56 min perfusion time (). Asterisks () in (b) indicate statistically significant differences () when compared to the control condition (absence of boldine), as given by the post hoc Student-Newman-Keuls testing.

(a)

(b)