Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients

Table 5

Mutations and amino acid substitutions in the PreS1-S region.

Region	Mutation	aa substitution	Mutation possible effect	Reference
PreS1; (2848–3171 nt)	A2965C	T40P	U	Current study
	G3082A	A79T	U	Current study
	T3100G	S85A	U	Current study
	A3154G	N103D	U	Current study
PreS2; (3172−154 nt)	T96C	L36P	U	Current study
	C105T	A39V	HCC	[29]
	C111A	P41H	U	Current study
	T113A	L43I	U	Current study
	A141G	D51G	U	Current study
S; (155–835 nt)	A162G	N3S	U	[30]
	G183A	G10R	U	Current study
	T213C	F20S	U	Current study
	G225A	R24K	HCC	[31]
	C242A	Q30K	U	Current study
	T279G	L42R	U	Current study
	T528C	M125T	IE	[32]
	A533C	T127P	U	Current study
	T678C	L175S	U	Current study
	C732T	S193L	U	Current study
	C762G	P203R	U	Current study

Bold font mutation: indicated known referenced mutation, aa: amino acid, HCC: hepatocellular carcinoma, IE: immune escape, U: uncharacterized effect.