Research Article
Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients
Table 6
Mutations and amino acid substitutions in the P region.
| | Region | Mutation | aa substitution | Mutation effect | Reference |
| TP domain
(2307–2837 nt) | A2326G | H7R | U | Current study | | C2354G | D16E | U | Current study | | G2565A | D87N | U | Current study | | A2588C | Q94H | U | Current study | | T2660G | K118N | U | Current study | | G2661A | V119I | U | Current study | | A2797G | H164R | U | Current study | | G2812A | C169Y | U | Current study |
| Spacer domain
(2838–129 nt) | G2840A | D178E | U | Current study | | C2928T | R31C | U | Current study | | A2965C | H43P | U | Current study | | C2976T | R47C | U | Current study | | T3012A | F59I | U | Current study | | T3075C | F80L | U | Current study | | G3082A | S82N | U | Current study | | T3100G | L88R | U | Current study | | C3102T | H89Y | U | Current study | | G3135T | A100S | U | Current study | | A3154G | K106R | U | Current study | | T1C | F116L | U | Current study | | T113A | L153H | U | Current study |
| RT domain
(130–1161 nt) | G182A | R18K | U | Current study | | T190G | S21A | U | Current study | | C242A | A38E | U | Current study | | C493T | L122F | U | Current study | | C493G | L122V | U | Current study | | A499C | N124H | U | Current study | | A511C | T128P | U | Current study | | A514T | M129L | U | Current study | | C518A | P130Q | U | Current study | | A520G | D131N | U | Current study | | A533C | Y135S | U | Current study | | C787A | L220I | U | Current study | | A871C | N249H | U | Current study | | A918T | E264D | U | Current study | | G961A | I278V | LVR | [33] | | C1084A | Q319L | U | Current study |
| RNase H domain
(1162–1620 nt) | T1249C
C1250T | S30L | U | Current study | T1249C
C1250G | S30R | U | Current study | T1249C
C1250A | S30Q | U | Current study | A1324C
C1326T | I55L | U | Current study |
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Bold font mutation: indicated known referenced mutation, aa: amino acid, LVR: low viral replication, U: uncharacterized effect.
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