Sex-Related Differences in Outcomes for Oropharyngeal Squamous Cell Carcinoma by HPV Status
Table 1
Baseline cohort characteristics by sex.
HPV positive
HPV negative
Characteristic
Men N = 8,860
Women N = 1,350
value
Men N = 3,020
Women N = 953
value
Age category, median (IQR)
60–64 (50–69)
60–64 (55–69)
<0.001
60–64 (55–69)
60–64 (55–74)
<0.001
Race/ethnicity, N (%)
Caucasian
7,613 (85.9)
1,103 (81.7)
0.001
2,270 (75.2)
731 (76.7)
0.06
African American
454 (5.1)
98 (7.3)
394 (13.1)
118 (12.4)
Hispanic
509 (5.7)
93 (6.9)
223 (7.4)
52 (5.5)
Asian or Pacific Islander
200 (2.3)
43 (3.2)
104 (3.4)
46 (4.8)
Other/unknown
84 (1.0)
13 (1.0)
29 (1.0)
6 (0.6)
Year of diagnosis, N (%)
2010
445 (5.0)
64 (4.7)
0.90
227 (7.5)
58 (6.1)
0.10
2011
676 (7.6)
114 (8.4)
358 (11.9)
125 (13.1)
2012
986 (11.1)
158 (11.7)
414 (13.7)
126 (13.2)
2013
1,312 (14.8)
205 (15.2)
479 (15.9)
140 (14.7)
2014
1,575 (17.8)
238 (17.6)
519 (17.2)
153 (16.1)
2015
1,777 (20.1)
260 (19.3)
464 (15.4)
182 (19.1)
2016
2,089 (23.6)
311 (23.0)
559 (18.5)
169 (17.7)
Stage at diagnosis, N (%)
I
5,098 (57.5)
878 (65.0)
<0.001
214 (7.1)
121 (12.7)
<0.001
II
2,097 (23.7)
255 (18.9)
250 (8.3)
101 (10.6)
III
1,451 (16.4)
181 (13.4)
563 (18.6)
170 (17.8)
IV
214 (2.4)
36 (2.7)
—
—
IVA
—
—
1,517 (50.2)
427 (44.8)
IVB
—
—
296 (9.8)
77 (8.1)
IVC
—
—
180 (6.0)
57 (6.0)
Clinical T∗, N (%)
0
61 (0.7)
6 (0.4)
<0.001
5 (0.2)
4 (0.4)
0.004
1
2,504 (28.3)
470 (34.8)
649 (21.5)
251 (26.3)
2
3,560 (40.2)
542 (40.2)
1,004 (33.3)
284 (29.8)
3
1,525 (17.2)
165 (12.2)
662 (21.9)
181 (19.0)
4
1,210 (13.7)
167 (12.4)
—
—
4a
—
—
467 (15.5)
157 (16.5)
4b
—
—
174 (5.8)
66 (6.9)
Missing
—
—
59 (2.0)
10 (1.0)
Clinical N†, N (%)
0
1,178 (13.3)
247 (18.3)
<0.001
746 (24.7)
325 (34.1)
<0.001
1
5,751 (64.9)
871 (64.5)
533 (17.7)
166 (17.4)
2
1,534 (17.3)
198 (14.7)
31 (1.0)
10 (1.1)
2a
—
—
217 (7.2)
57 (6.0)
2b
—
—
797 (26.4)
216 (22.7)
2c
—
—
468 (15.5)
140 (14.7)
3
397 (4.5)
34 (2.5)
177 (5.9)
29 (3.0)
Missing
—
—
51 (1.7)
10 (1.0)
Median county Household income, $
63,880
63,250
0.10
61,020
61,020
0.45
% County education, median
<9th grade
5.18
5.29
0.97
5.26
4.88
0.13
< High school
12.10
12.32
0.52
12.50
12.45
0.05
≥ Bachelors
32.59
31.93
0.35
31.23
31.23
0.33
Insurance, N (%)
Uninsured
239 (2.7)
26 (1.9)
<0.001
132 (4.4)
36 (3.8)
0.41
Any Medicaid
783 (8.8)
158 (11.7)
521 (17.3)
182 (19.1)
Insured
6,702 (75.6)
960 (71.1)
1,871 (62.0)
567 (59.5)
Insured (no specifics)
1,036 (11.7)
184 (13.6)
441 (14.6)
153 (16.1)
Unknown
100 (1.1)
22 (1.6)
55 (1.8)
15 (1.6)
Marital status, N (%)
Single
2,835 (32.0)
612 (45.3)
<0.001
1,309 (43.3)
508 (53.3)
<0.001
Married
5,620 (63.4)
681 (50.4)
1,576 (52.2)
382 (40.1)
Unknown
405 (4.6)
57 (4.2)
135 (4.5)
63 (6.6)
HPV, human papillomavirus; IQR, interquartile range, HPV positive: 16.0% clinical, 7.5% pathologic; HPV negative: 13.7% clinical, 4.5% pathologic; the rest based on best available information as determined by SEER. †HPV positive: 16.8% clinical, 6.7% pathologic; HPV negative: 14.4% clinical, 3.8% pathologic; the rest based on best available information as determined by SEER.
