Research Article

Sex-Related Differences in Outcomes for Oropharyngeal Squamous Cell Carcinoma by HPV Status

Table 2

Recommended treatment by stage, HPV status, and sex.

Recommended treatmentHPV positiveHPV negative
Men N = 8,860Women N = 1,350 valueMen N = 3,020Women N = 953 value

All stages, N (%)
 No1,640 (18.5)305 (22.6)0.002538 (17.8)202 (21.2)0.06
 Yes7,198 (81.2)1,042 (77.2)2,474 (81.9)748 (78.5)
 Missing22 (0.3)3 (0.2)8 (0.3)3 (0.3)

Stage I, N (%)N = 5,098N = 8780.02N = 214N = 1210.18
 No1,071 (21.0)220 (25.1)17 (7.9)5 (4.1)
 Yes4,013 (78.7)655 (74.6)197 (92.1)116 (95.9)
 Missing14 (0.3)3 (0.3)0 (0.0)0 (0.0)

Stage II, N (%)N = 2,097N = 2550.30N = 250N = 1010.59
 No240 (11.4)37 (14.5)20 (8.0)5 (5.0)
 Yes1,854 (88.4)218 (85.5)227 (90.8)95 (94.1)
 Missing3 (0.1)0 (0.0)3 (1.2)1 (1.0)

Stage III, N (%)N = 1,451N = 1810.70N = 563N = 1700.03
 No247 (17.0)34 (18.8)64 (11.4)32 (18.8)
 Yes1,201 (82.8)147 (81.2)498 (88.5)137 (80.6)
 Missing3 (0.2)0 (0.0)1 (0.2)1 (0.6)

Stage IV (A/B/C), N (%)N = 214N = 360.84N = 1,993N = 5610.005
 No82 (38.3)14 (38.9)437 (21.9)160 (28.5)
 Yes130 (60.8)22 (61.1)1,552 (77.9)400 (71.3)
 Missing2 (0.9)0 (0.0)4 (0.2)1 (0.2)

Abbreviations: HPV, human papillomavirus; N, number; %, percentage of total.