Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Intima-Media Thickness: Systematic Review and Meta-Analysis

Table 2

Publication bias evaluation by Egger’s regression test and Duval and Tweedie trim and fill test.

Finding/distribution pattern	Egger’s test		Trim and fill method
	Egger’s intercept	value	Number of trimmed studies	Point estimate after trim	Change after trim
Baseline-final GLP-1 RA	-1.191	0.706	1	-0.113	0.010
Baseline-final GLP-1 RA (RCTs)	-1.172	0.917	0	-0.119	0.000
Baseline-final GLP-1 RA (T2DM)	-1.685	0.565	0	-0.196	0.000
Baseline-final liraglutide	-2.523	0.590	0	-0.127	0.000
Baseline-final exenatide	-5.933	0.581	0	-0.240	0.000
GLP-1 RA compared to control	-6.759	0.085	0	-0.398	0.000
Baseline-final SGLT2i	0.621	0.816	0	-0.048	0.000
Baseline-final SGLT2i (RCTs)	5.190	0.629	0	-0.043	0.000

RCT: randomized clinical trial; T2DM: type 2 diabetes mellitus; GLP-1 RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors.