Insulin Secretion Defect in Children and Adolescents with Obesity: Clinical and Molecular Genetic Characterization

Figure 2

Hyperbolic relationship of insulin secretion (measured by Matsuda index) and insulin sensitivity (measured by Total AUC (Ins/Glu)). NGT: normal glucose tolerance; IGT: impaired glucose tolerance; T2D: type 2 diabetes; Ins: insulin; Glu: glucose; AUC: area under the curve; ABCC8: ATP binding cassette subfamily C member 8; GCK: glucokinase; PTF1A: pancreas associated transcription factor 1a, GLI2: GLI family zinc finger 2.