Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice

Figure 4

(a) Overlap between disease genes from the DrugBank database (disease gene), differentially expressed genes from the GSE38642 dataset (GEO data), drug targets from the DrugBank (drug targets), and compounds’ targets mainly from the TCMSP and ETCM databases (compound targets); (b) top ten hub genes in 106 genes ranked by Maximal Clique Centrality (MCC) in cytoHubba plugin of Cytoscape; (c) top ten hub genes in 106 genes ranked by EcCentricity in cytoHubba plugin of Cytoscape; (d) significantly enriched GO terms and KEGG pathways of 106 genes from overlaps of compound targets and disease genes (BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes); (e) compound-target network. The square nodes represent the bioactive compounds, the oval nodes represent the predicted targets, and the color of the nodes was mapped according to the degree.

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