Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice

Figure 2

Perturbations in serum lipids, liver triglycerides, and alanine aminotransferase (ALT) with age, diet, and genotype. Serum cholesterol, HDL, LDL, and VLDL (a), serum and liver triglycerides (b), and serum ALT (c) were measured in all treatment groups using standard methods. Data are presented as . Statistical significance was determined by one-way ANOVA followed by Tukey’s multiple comparison test as the post hoc test (). “a” indicates age difference comparing young (4.5 mo) and old (9 mo) mice within the same genotype and diet group, “c” indicates difference between HFD-fed young (4.5 mo) and ND-fed old (9 mo) mice within same genotype, “d” indicates diet difference between ND-fed and HFD-fed mice within in same genotype and age, and “g” indicates genotype difference between WT and Cyp2b-null mice within same diet and age group. No asterisk indicates a value < 0.05, indicates a value < 0.01, and indicates a values < 0.0001.

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