Journal of Nucleic Acids / 2021 / Article / Tab 5 / Review Article
DNAzymes, Novel Therapeutic Agents in Cancer Therapy: A Review of Concepts to Applications Table 5 Clinical trials of DNAzymes in cancer treatment.
mRNA target DNAzyme Patient type Phase Trial size Transfection reagent Dose regime Reference c-jun Dz13 BCC 1 9 DOTAP/DOPE Three dose groups (10, 30, and 100 μ g of Dz13) with three patients per group. Single intratumoral administration of 50 μ L of Dz13 over four weeks [63 ] EBV-LMP DZ1 NPC 1 40 Saline Administration into the tumor under the local anesthetization via an epical endoscope at a dose of of saline per injection twice weekly over seven weeks [124 ]