Squamous Cell Carcinoma Arising from Chronic Osteomyelitis in the Extremities: Treatment Approach and Oncological Outcomes—A Systematic Review of the Literature

Table 4

Treatment modalities and associated risk of recurrence, metastasis, and/or all-cause death. AKA: above-the-knee amputation, BKA: below-the-knee amputation.

	Recurrence	Metastasis	Mean-survival (months)	All-cause death
Type of treatment
Amputation	5.56% (2/36)	8.33% (3/36)	39.91 ± 27.63	20.59% (7/34)
Limb salvage	33.33% (1/3)	0 (0/2)	24 ± 21.63	0 (0/2)
values	0.219	0.846	0.3116	0.644
Treatment modality
AKA	0 (0/16)	6.25% (1/16)	47.23 ± 31.01	33.33% (5/15)
BKA	10% (1/10)	0 (0/10)	45.78 ± 22.03	0 (0/9)
Ray amputation	0 (0/2)	0 (0/2)	10.5 ± 2.12	0 (0/2)
Foot amputation	0 (0/2)	0 (0/2)	42 ± 42.43	0 (0/2)
Hip disarticulation	0 (0/3)	33.33% (1/3)	30 ± 26.63	33.33% (1/3)
Resection	33.33% (1/3)	0 (0/2)	24 ± 21.63	0 (0/2)
Hemipelvectomy	0 (0/1)	100% (1/1)	2	100% (1/1)
Transhumeral amputation	100% (1/1)	0 (0/1)	36	0 (0/1)
Digit amputation	0 (0/1)	0 (0/1)	16	0 (0/1)
AKA vs. BKA
AKA	0 (0/16)	6.25% (1/16)	47.23 ± 31.01	33.33% (5/15)
BKA	10% (1/10)	0 (0/10)	45.78 ± 22.03	0 (0/9)
values	0.385	0.615	0.8910	0.071