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Diagnostic technique | Commercially available technologies | Advantages | Disadvantages |
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Dermoscopy | Delta® 20 T Dermlite® Veos® | Better overall diagnostics, prior surgical intervention | Low quality, little depth of engagement, extra instruction needed |
Multiphoton microscopy | DermaInspect® | Confinement of data to a single layer, extremely fine resolution down to the subcellular level, wide area coverage | Low signal strength, high acquisition time, susceptibility to artifacts introduced by motion, high cost |
Dermatofluoroscopy | DermaFC® | Spectra of melanin are extremely sensitive, allowing for a scientifically sound detection process | Lesion depth information is lacking; only pigmented lesions can be detected |
Reflectance confocal microscopy | Vivascope | Extensive correlation with histology, high precision, cellular resolution, better contrast image | Insufficient detecting range and depth, as well as a lengthy learning curve, important to have healthy skin, expensive, needs lots of practice to be effective |
Optical coherence tomography | Vivosight® Skintell® | Intense imaging, fast picture capture, vertical imaging; imaging of vasculature | Inadequate resolution (with the exception of HD-OCT), expensive, preferable used on healthy skin, extra instruction needed |
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