Bisphenol-A Abrogates Proliferation and Differentiation of C2C12 Mouse Myoblasts via Downregulation of Phospho-P65 NF-κB Signaling Pathway

Figure 2

BPA induced cell cycle arrest and reduced antioxidant enzyme activity. C2C12 myoblast cells were cultured in a growth medium in the absence or presence of BPA for 72 h. The treated cells were collected, stained with propidium iodide, and subjected to flow cytometry for cell cycle analysis. Cell cycle distribution graph (a) and percentage of cell population in subG1, G0/G1, and S and G2/M phases (b). The treated cells were subjected to protein extraction and antioxidant enzyme activity determination (c). , ; compared to the control group.

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