Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats
Table 1
Hematological parameters of S-D rats after 14 days of administration of CMASE.
Hematological parameters
Rat groups
Control
Low dose 1000 mg/kg
Median dose 2500 mg/kg
High dose 5000 mg/kg
value
WBC × 103 (μl)
13.42 ± 1.60
12.53 ± 2.21
11.95 ± 1.46
14.39 ± 1.57
0.770
RBC × 106 (μl)
8.35 ± 0.15
7.99 ± 0.29
7.86 ± 0.13
8.57 ± 0.40
0.285
HGB (g/dL)
14.73 ± 0.25
14.14 ± 0.53
14.00 ± 0.31
15.28 ± 0.25
0.077
HCT (%)
47.73 ± 0.73
45.44 ± 2.07
44.50 ± 0.72
48.58 ± 1.68
0.190
MCV (fL)
57.18 ± 1.33
56.92 ± 1.69
56.64 ± 0.8
56.78 ± 1.05
0.992
MCH (pg)
17.63 ± 0.35
17.72 ± 0.49
17.58 ± 0.32
17.88 ± 0.42
0.954
MCHC (g/dl)
30.85 ± 0.22
31.18 ± 0.26
32.48 ± 1.2
31.45 ± 0.15
0.323
PLT × 103 (μl)
767 ± 96.7
576.8 ± 26.85
533.8 ± 50.97
631 ± 29.37
0.059
LYM (%)
68.65 ± 2.23
74.52 ± 3.25
68.06 ± 2.26
71.33 ± 2.39
0.302
LYM (# ×103/μl)
9.25 ± 1.24
9.31 ± 1.75
8.40 ± 0.93
10.38 ± 1.46
0.792
Data are presented as mean ± SEM. n = 5. values were obtained from one-way ANOVA (treatment groups compared to control for each parameter). Since, values were greater than 0.05, thus there were no significant differences between treatment and control groups. WBC = white blood cells; RBC = red blood cells; HGB = hemoglobin levels; HCT = hematocrit; MCV = mean cell volume; MCH = mean corpuscular hemoglobin; MCHC = mean cell hemoglobin concentration; PLT = platelet counts; LYM = lymphocytes.
