Research Article
Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.
Table 2
Body weight, organ weights, and relative organ weights of female rats treated orally with CECPM for 90 days.
| Parameters | Groups | Control | CECPM (600 mg/kg bw) | CECPM (800 mg/kg bw) | CECPM (1000 mg/kg bw) | Satellite | Control | CECPM (1000 mg/kg bw) |
| Body weight | Initial weight (g) | 181.62 ± 25.05 | 191.50 ± 25.53 | 185.52 ± 19.61 | 176.53 ± 22.65 | 195.08 ± 18.92 | 186.27 ± 16.92 | Final weight (g) | 226.33 ± 29.26 | 230.04 ± 22.03 | 226.69 ± 18.60 | 215.97 ± 27.26 | 245.27 ± 21.88 | 236.26 ± 16.70 | Bogy weight gain (g) | 44.71 ± 19.87 | 38.54 ± 13.06 | 41.17 ± 21.09 | 42.31 ± 16.00 | 50.19 ± 21.13 | 49.99 ± 15.46 | Food intake (g) | 20.68 ± 2.68 | 20.92 ± 1.77 | 20.35 ± 2.08 | 21.13 ± 2.67 | 21.25 ± 1.62 | 19.98 ± 1.77 | Organ weight | Kidney (g) | 1.47 ± 0.20 | 1.55 ± 0.27 | 1.48 ± 0.19 | 1.39 ± 0.16 | 1.55 ± 0.20 | 1.49 ± 0.11 | Liver (g) | 6.14 ± 1.02 | 6.63 ± 0.94 | 6.25 ± 0.75 | 5.99 ± 0.76 | 6.50 ± 0.69 | 6.60 ± 0.71 | Spleen (g) | 0,50 ± 0.07 | 0.48 ± 0.08 | 0.43 ± 0.06 | 0.51 ± 0.13 | 0.49 ± 0.08 | 0.44 ± 0.08 | Heart (g) | 0.79 ± 0.09 | 0.79 ± 0.14 | 0.76 ± 0.09 | 0.78 ± 0.09 | 0.84 ± 0.09 | 0.82 ± 0.08 | Lung (g) | 2.31 ± 0.59 | 2.45 ± 0.63 | 2.18 ± 0.66 | 2.28 ± 0.81 | 2.27 ± 0.65 | 2.07 ± 0.81 | Relative organ weight | Kidney (%) | 0.65 ± 0.03 | 0.67 ± 0.08 | 0.65 ± 0.04 | 0.65 ± 0.04 | 0.63 ± 0.07 | 0.63 ± 0.02 | Liver (%) | 2.71 ± 0.22 | 2.87 ± 0.17 | 2.75 ± 0.16 | 2.78 ± 0.14 | 2.66 ± 0.25 | 2.80 ± 0.24 | Spleen (%) | 0.22 ± 0.02 | 0.21 ± 0.03 | 0.19 ± 0.02a | 0.24 ± 0.05 | 0.20 ± 0.03 | 0.18 ± 0.03 | Heart (%) | 0.35 ± 0.03 | 0.21 ± 0.03 | 0.34 ± 0.03 | 0.36 ± 0.03 | 0.34 ± 0.03 | 0.35 ± 0.04 | Lung (%) | 1.03 ± 0.30 | 1.07 ± 0.27 | 0.96 ± 0.26 | 1.05 ± 0.33 | 0.93 ± 0.27 | 0.87 ± 0.33 |
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Data are expressed as the means ± SD of ten animals in each group. a compared to the control group. |