Systematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis: Advances and Challenges

Table 5

Summary estimates of diagnostic accuracy of molecular and bioassay techniques for the diagnosis of T. gondii infection.

Parameter	PCR–AF			Bio–AF			PCR–PLA			Bio–PLA
	Estimate	2.5% CI	97.5% CI	Estimate	2.5% CI	97.5% CI	Estimate	2.5% CI	97.5% CI	Estimate	2.5% CI	97.5% CI
Sensitivity	0.851	0.695	0.934	0.574	0.416	0.718	0.589	0.585	0.593	0.586	0.472	0.692
Specificity	0.997	0.972	1.000	0.993	0.936	0.999	0.963	0.963	0.964	0.995	0.979	0.999
Random effects correlation	−0.572			1.000			−0.365			−1.000
Diagnostic odds ratio	2018.385	228.652	17816.960	189.944	13.453	2681.756	37.706	36.843	38.588	258.867	69.775	960.405
Likelihood ratio (LR+)	302.048	30.916	2950.945	81.498	7.388	899.084	16.085	15.815	16.360	107.661	28.853	401.718
Likelihood ratio (LR−)	0.150	0.069	0.325	0.429	0.295	0.623	0.427	0.422	0.431	0.416	0.318	0.544

PCR: polymerase chain reaction; AF: amniotic fluid; Bio: bioassay; PLA: placenta.