[¹⁸F]-(2S,4R)4-Fluoroglutamine PET Imaging of Glutamine Metabolism in Murine Models of Hepatocellular Carcinoma (HCC)

Table 1

Relative expression for major glutamine influx transporters and catabolism enzymes in the normal liver, MYC HCC, and MET HCC tissues based on the microarray studies.

	Gene name	Average Log2 expression
		Normal liver	MYC HCC	MET HCC
Glutamine influx transporters	SLC1A5	6.09	8.40 ()	7.18 ()
	SLC6A14	4.93	4.75	4.70
	SLC6A19	5.35	5.80	5.50
	SLC7A5	6.68	8.75 ()	8.20 ()
	SLC7A6	6.32	8.55 ()	6.37
	SLC7A7	7.20	8.23 ()	8.38 ()
	SLC38A1	5.13	5.20	4.79
	SLC38A2	9.61	9.78	9.67
	SLC38A5	6.44	6.20	6.29
	SLC38A7	6.94	6.82	7.15
	SLC38A8	6.13	6.10	6.19
Glu catabolism emzymes	Gls	5.81	9.07 ()	6.08
	Gls2	8.42	7.73 ()	6.32 ()
	Glul	9.75	8.39 ()	11.9 ()

. Bold: upregulated in HCC. Italic: downregulated in HCC.