First-in-Human PET Imaging of [¹⁸F]SDM-4MP3: A Cautionary Tale

Figure 6

HPLC chromatograms (a) and mass spectrometry (MS) analysis (b) from precursors obtained from ABX and Yale. Precursor from an alternative commercial supplier (PharmaSynth) was also tested but was not appreciably different from the lot obtained from Yale (data not shown). The retention times for both samples were 3.30 min (ABX) and 3.31 min (Yale). The fragmentations seen in the mass spectra are similar, albeit with differing intensities, 449.3 [M+H]⁺ and 490.3 and the [M+CH₃CN+H]⁺ signals are clearly detectable in both mass spectra.

(a)

(b)