Research Article
Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models
Table 1
Biochemical evaluation of oxidant-antioxidant and cardiac injury markers in ISO induced model of myocardial necrosis.
| Groups | GSH (mg/g of tissue) | MDA (µM/g of tissue) | SOD (U/mg of protein) | CAT (U/ml) | CK-MB (U/l) | LDH (U/l) |
| Normal | 6.03 ± 0.62 | 0.34 ± 0.03 | 12.48 ± 0.63 | 6.28 ± 0.45 | 350.3 ± 17.15 | 323.8 ± 15.20 | ISO-C | 3.19 ± 0.38 | 0.62 ± 0.02 | 6.38 ± 0.52 | 2.15 ± 0.61 | 698.2 ± 47.63 | 701.9 ± 53.17 | Abata2.5 + ISO | 4.90 ± 0.73 | 0.48 ± 0.04# | 7.53 ± 0.38 | 4.61 ± 0.38# | 491.9 ± 35.73### | 605.2 ± 52.38### | Abata5 + ISO | 5.82 ± 0.36# | 0.41 ± 0.02### | 10.10 ± 0.46### | 5.2 ± 0.51## | 372.6 ± 20.62### | 498.3 ± 19.52### | Abata10 + ISO | 6.1 ± 0.82# | 0.39 ± 0.03### | 11.48 ± 0.62### | 5.8 ± 0.31### | 341.3 ± 23.46### | 443.4 ± 21.30### |
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, , . ISO-C, isoproterenol control; ABT2.5+ISO, Abatacept 2.5 mg/kg+isoproterenol; ABT5+ISO, Abatacept 5 mg/kg+isoproterenol; ABT10+ISO, Abatacept 10 mg/kg + isoproterenol; GSH, glutathione; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; CK-MB, creatine kinase−myocardial band; LDH, lactate dehydrogenase. |