The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents
Table 2
Spearman correlations and ICCs of each fasting and OGTT-derived insulin sensitivity measure between visits 1 and 2 and the p value of the Spearman correlation comparison between fasting vs. OGTT-derived measures.
Measurement comparison
All participants
Overweight/obese
Normal weight
Fasting measure
OGTT-derived measure
Fasting correlation (V1 vs. V2)
OGTT-derived correlation (V1 vs. V2)
p Value
Fasting ICC (V1 vs. V2)
OGTT-derived ICC (V1 vs. V2)
Fasting correlation (V1 vs. V2)
OGTT-derived correlation (V1 vs. V2)
p Value
Fasting ICC (V1 vs. V2)
OGTT-derived ICC (V1 vs. V2)
Fasting correlation (V1 vs. V2)
OGTT-derived correlation (V1 vs. V2)
p Value
Fasting ICC (V1 vs. V2)
OGTT-derived ICC (V1 vs. V2)
Insulin sensitivity
HOMA-IR
WBISI
0.73 (0.66–0.78)
0.83 (0.79–0.87)
<0.001
0.73 (0.67–0.78)
0.80 (0.75–0.84)
0.72 (0.64–0.78)
0.80 (0.74–0.84)
<0.001
0.71 (0.63–0.77)
0.75 (0.68–0.81)
0.53 (0.34–0.68)
0.83 (0.74–0.89)
<0.001
0.50 (0.31–0.65)
0.79 (0.68–0.86)
QUICKI
WBISI
0.73 (0.66–0.78)
0.83 (0.79–0.87)
<0.001
0.72 (0.66–0.77)
0.80 (0.75–0.84)
0.72 (0.64–0.78)
0.80 (0.74–0.84)
<0.001
0.73 (0.66–0.79)
0.75 (0.68–0.81
0.53 (0.34–0.68)
0.83 (0.74–0.89)
<0.001
0.50 (0.31–0.65)
0.79 (0.68–0.86)
FGIR
WBISI
0.76 (0.71–0.81)
0.83 (0.79–0.87)
<0.001
0.67 (0.60–0.73)
0.80 (0.75–0.84)
0.75 (0.68–0.81)
0.80 (0.74–0.84)
<0.001
0.70 (0.62–0.77)
0.75 (0.68–0.81
0.58 (0.40–0.71)
0.83 (0.74–0.89)
0.08
0.48 (0.28–0.64)
0.79 (0.68–0.86)
1/fasting insulin
WBISI
0.75 (0.70–0.80)
0.83 (0.79–0.87)
<0.001
0.66 (0.58–0.72)
0.80 (0.75–0.84)
0.75 (0.68–0.81)
0.80 (0.74–0.84)
<0.001
0.69 (0.61–0.76)
0.75 (0.68–0.81
0.54 (0.35–0.69)
0.83 (0.74–0.89)
0.03
0.46 (0.26–0.62)
0.79 (0.68–0.86)
Insulin secretion
HOMA-B
IGI
0.69 (0.62–0.75)
0.61 (0.53–0.68)
0.08
0.30 (0.18–0.41)
−0.01 (−0.13–0.11)
0.68 (0.59–0.75)
0.56 (0.45–0.65)
0.72
0.26 (0.12–0.39)
−0.04 (−0.18–0.10)
0.61 (0.44–0.74)
0.65 (0.49–0.77)
0.05
0.60 (0.43–0.73)
0.31 (0.09–0.50)
HOMA-B
DI
0.69 (0.62–0.75)
0.52 (0.42–0.60)
0.002
0.30 (0.18–0.41)
−0.06 (−0.18–0.06)
0.68 (0.59–0.75)
0.49 (0.37–0.59)
0.77
0.26 (0.12–0.39)
−0.11 (−0.25–0.03)
0.61 (0.44–0.74)
0.58 (0.40–0.72)
0.005
0.60 (0.43–0.73)
0.13 (−0.10–0.35)
Comparisons of Spearman correlations were performed overall and then specifically for overweight/obese participants and normal weight participants. .
