The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents

Table 3

Spearman correlations and ICCs of insulin sensitivity and secretion measures between visits 1 and 2, and p values of the Spearman correlation comparison between overweight/obese vs. normal weight, Black vs. White, male vs. female, pre-midpuberty vs. post-midpubertal children.

Category

Measures

Overweight/obese vs. normal weight

Black vs. White

Male vs. female

Pre- vs. post-midpuberty

OV/OB; correlation

Normal weight; correlation

p-Value

OV/OB ICC

Normal weight ICC

Black correlation

White; correlation

p-Value

Black ICC

White ICC

Male; correlation

Female; correlation

p-Value

Male ICC

Female ICC

Pre-midpuberty; correlation

Post-midpuberty; correlation

p-Value

Pre-midpuberty; ICC

Post-midpuberty; ICC

Insulin sensitivity

HOMA-IR

0.72 (0.64–0.78)

0.53 (0.34–0.68)

0.03

0.71 (0.63–0.77)

0.50 (0.31–0.65)

0.76 (0.63–0.85)

0.74 (0.66–0.81)

0.83

0.38 (0.15–0.57)

0.82 (0.76–0.87)

0.72 (0.61–0.79)

0.72 (0.63–0.79)

0.91

0.83 (0.76–0.88)

0.66 (0.56–0.74)

0.73 (0.61–0.82)

0.73 (0.65–0.79)

0.97

0.63 (0.48–0.75)

0.79 (0.73–0.84)

QUICKI

0.72 (0.64–0.78)

0.53 (0.34–0.68)

0.03

0.73 (0.66–0.79)

0.50 (0.31–0.65)

0.76 (0.63–0.85)

0.74 (0.66–0.81)

0.83

0.67 (0.51–0.78)

0.75 (0.67–0.81)

0.72 (0.61–0.79)

0.72 (0.63–0.79)

0.91

0.73 (0.63–0.80)

0.72 (0.63–0.79)

0.73 (0.61–0.82)

0.73 (0.65–0.79)

0.97

0.70 (0.67–0.80)

0.74 (0.67–0.80)

FGIR

0.75 (0.68–0.81)

0.56 (0.40–0.71)

0.02

0.70 (0.62–0.77)

0.48 (0.28–0.64)

0.82 (0.71–0.88)

0.76 (0.68–0.82)

0.33

0.66 (0.50–0.78)

0.68 (0.59–0.76)

0.75 (0.66–0.82)

0.76 (0.68–0.82)

0.89

0.66 (0.54–0.75)

0.67 (0.57–0.75)

0.74 (0.61–0.82)

0.77 (0.70–0.82)

0.59

0.65 (0.50–0.76)

0.69 (0.61–0.76)

1/Fasting insulin

0.75 (0.68–0.81)

0.54 (0.35–0.69)

0.01

0.69 (0.61–0.76)

0.46 (0.26–0.62)

0.80 (0.68–0.87)

0.76 (0.68–0.82)

0.53

0.65 (0.48–0.77)

0.67 (0.57–0.75)

0.74 (0.65–0.79)

0.78 (0.68–0.82)

0.76

0.64 (0.52–0.74)

0.68 (0.58–0.76)

0.75 (0.63–0.83)

0.76 (0.69–0.81)

0.84

0.64 (0.49–0.75)

0.68 (0.59–0.75)

WBISI

0.80 (0.74–0.84)

0.83 (0.74–0.89)

0.54

0.75 (0.68–0.81)

0.79 (0.68–0.86)

0.81 (0.70–0.88)

0.86 (0.81–0.89)

0.26

0.78 (0.66–0.86)

0.83 (0.77–0.87)

0.85 (0.78–0.89)

0.81 (0.75–0.86)

0.41

0.81 (0.74–0.86)

0.78 (0.71–0.84)

0.82 (0.73–0.61)

0.84 (0.79–0.88)

0.72

0.84 (0.76–0.89)

0.78 (0.72–0.83)

Insulin secretion

HOMA-B

0.68 (0.59–0.75)

0.61 (0.44–0.74)

0.43

0.26 (0.12–0.39

0.60 (0.43–0.73)

0.71 (0.56–0.81)

0.68 (0.58–0.75)

0.66

0.26 (0.02–0.47)

0.61 (0.50–0.70)

0.71 (0.60–0.79)

0.66 (0.55–0.74)

0.48

0.72 (0.62–0.80)

0.23 (0.07–0.38)

0.66 (0.52–0.77)

0.70 (0.61–0.76)

0.66

0.24 (0.02–0.44)

0.34 (0.20–0.46)

IGI

0.56 (0.45–0.65)

0.65 (0.49–0.77)

0.33

−0.04 (−0.18–0.10)

0.31 (0.09–0.50)

0.55 (0.35–0.70)

0.62 (0.50–0.70)

0.53

−0.07 (−0.31–0.17)

0.22 (0.07 –0.36)

0.67 (0.55–0.76)

0.55 (0.43–0.67)

0.14

0.51 (0.36–0.63)

−0.07 (−0.23–0.10)

0.66 (0.51–0.77)

0.59 (0.48–0.68)

0.39

0.36 (0.15–0.54)

−0.04 (−0.18 –0.11)

DI

0.49 (0.37–0.59)

0.58 (0.40–0.72)

0.36

−0.11 (−0.25–0.03)

0.13 (−0.10 –0.35)

0.49 (0.27–0.65)

0.54 (0.42–0.65)

0.61

−0.12 (−0.35–0.12)

0.04 (−0.12–0.20)

0.64 (0.51–0.73)

0.41 (0.27–0.54)

0.01

0.30 (0.13–0.46)

−0.09 (−0.25 –0.08)

0.61 (0.44–0.73)

0.48 (0.36–0.58)

0.19

0.17 (−0.05–0.38)

−0.07 (−0.21 –0.08)