Research Article
Elevated Serum IgA at Onset of Type 1 Diabetes in Children
Table 1
Characteristics of children with new onset T1D included in the analysis (n = 631).
| | Characteristics at diagnosis | |
| | Serum IgA levels % (N) | | Normal | 76.7% (484) | | High | 20.3% (128) | | Low | 3.0% (19) | | Male: % (N) | 52% (330) | | Age (years) | 9.9 (6.6–12.8) | | IgA at diagnosis (mg/dL) | 159 (108–218) | | Pubertal development stage: % (N) | | Prepubertal | 59% (343) | | Race/ethnicity: % (N) | | Non-Hispanic White race | 59% (362) | | Hispanic ethnicity (any race) | 20% (124) | | African American race | 16% (96) | | Asian race | 4.0% (25) | | Mixed race | 1.0% (7) | | Glucose (mg/dL) | 372 (270–508) | | HbA1c at diagnosis (%) | 11.8 (10.4–13.5) | | C-peptide, random (ng/mL) | 0.4 (0.28–0.71) | | pH | 7.33 (7.21–7.38) | | BOHB (mmol/L) | 4.1 (1.4–7.8) | | Bicarbonate (mmol/L) | 19.0 (10.2–24.0) | | DKA: % (N) | 36% (214) | | IA-2A (U/mL) | 8.4 (1.5–23.0) | | IA-2A positivity: % (N) | 79% (494) | | GADA (IU/mL) | 5.2 (0.93–29.5) | | GADA positivity: % (N) | 82% (511) | | Number of positive islet autoantibodies: % (N) | | 0 | 4% (22) | | 1 | 21% (133) | | 2 | 49% (307) | | 3 | 26% (159) | | IAA positivity: % (N) | 36% (228) | | IAA at diagnosis (U/mL) | 0.3 (0.3–1.1) | | tTG IgA positivity: % (N) | 11% (69) | | tTG IgA (U/mL) | 4 (2–9) | | Thyroid antibody positivity: % (N) | 51% (316) |
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a (b − c) represents the median a, the lower quartile b, and the upper quartile c for continuous variables.
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