NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats

Figure 1

Relationship between NGF/TrKA signaling pathway and KOA peripheral hyperalgesia. Notes. (a) The activation of NGF/TrkA promotes the release of pain-related neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P (SP) and activates TRPV1 on nociceptor terminal; NGF/TrKA complex is transported to DRG via cytokinesis. (b) The NGF/TrKA complex promotes DRG sensitivity and causes increased expression of TRPV1, PGP9.5, and S100, and it may also cause peripheral sensory nerve fiber sprouting.