NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats

<div>The protocol of animal experiment and the results of ACLT modeling. <i>Notes</i>. (a) Animal experimental protocol. (b) The anatomical changes in the knee. (c) HE (20x, scale bar = 500 <i>μ</i>m) and Safranin O‐Fast green staining (20x, scale bar = 500 <i>μ</i>m) of the cartilage and the HE staining of synovial tissues (40x, scale bar = 50 <i>μ</i>m).</div>

Pain Research and Management

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Figure 2

Figure 2: NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats 