NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats

<div>NGF-induced TRPV1-labeled nerve fiber sprouting. <i>Notes</i>. (a) The silver staining images of synovial tissues (20x, scale bar = 200 <i>μ</i>m). (b) The immunohistochemical staining images of synovial tissues, in which the target protein turns to brown particles after staining (20x, scale bar = 200 <i>μ</i>m). (c) The immunofluorescence staining images of TrKA, TRPV1, and PGP9.5 in the synovial tissues (40x, scale bar = 100 <i>μ</i>m).</div>

Pain Research and Management

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Figure 4

Figure 4: NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats 