Research Article

Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine

Table 1

IL-6 plasma levels and rs2228145 genotypic and allelic frequencies for SZ patients and controls. p: p value for the comparison of each group resistance vs. remission and resistance vs. control.

Median IL-6  
plasma levels (pg/ml)
Genotypic  
frequencies n (%)
Allelic  
frequencies n (%)
CCACAApCAp

Resistance1.91 8  
(34.8)
11  
(43.5)
5    (21.7)19    (47.5)21    (52.5)

Remission2.2514  
(36.1)
23  
(55.6)
4  
(8.3)
0.3551  
(62)
31    (38)0.17

ControlN.A.20  
(42)
21  
(44)
7  
(15)
0.7161    (63.5)35    (36.4)0.12