Polygenic Risk Scores for Subtyping of Schizophrenia
Table 1
Traits genetically related to schizophrenia.
Trait
MGS
SSCCS
CATIE
Estimate
Std.Err
Estimate
Std.Err
Estimate
Std.Err
BMI
−317.20
198.30
−1.60
0.1096
−504.37
166.03
−3.04
0.0024
−876.75
384.79
−2.28
0.0227
Cannabis
30.67
19.17
1.60
0.1097
44.29
16.62
2.67
0.0077
33.10
37.81
0.88
0.3813
evrSmk
271.40
79.98
3.39
0.0007
354.79
69.68
5.09
3.55E-07
285.55
149.62
1.91
0.0563
MEM
1215.00
306.20
3.97
7.21E-05
1198.37
258.63
4.63
3.60E-06
837.03
563.61
1.49
0.1375
NEW_BIP
901.60
50.65
17.80
2.00E-16
582.88
41.94
13.90
2.00E-16
775.78
95.36
8.14
4.10E-16
Openness
36.04
14.06
2.56
0.0104
26.49
11.80
2.25
0.0247
74.71
26.85
2.78
0.0054
OPPH
−1215.00
606.10
−2.01
0.0449
−790.07
506.85
−1.56
0.1190
−759.07
1023.04
−0.74
0.4581
SWB
−716.70
312.00
−2.30
0.0216
−967.25
262.97
−3.68
0.0002
170.78
590.56
0.29
0.7724
VNR
−618.60
159.50
−3.88
0.0001
−455.89
138.07
−3.30
0.0010
−523.70
320.92
−1.63
0.1027
YoS
973.50
426.90
2.28
0.0226
1318.65
361.70
3.65
0.0003
−827.34
819.49
−1.01
0.3127
MGS: Molecular Genetics of Schizophrenia; SSCCS: Swedish Schizophrenia Case-Control Study; CATIE: Clinical Antipsychotic Trials for Intervention Effectiveness; BMI: body mass index; Cannabis: cannabis dependence; evrSmk: ever smoker vs never smoker; MEM: working memory; NEW_BIP: PGC Phase II bipolar disorder; Openness: neoopenness; OPPH: one person income per household; SWB: subjective wellbeing; VNR: verbal and numeric reasoning; YoS: years of school attended.
