Research Article

Polygenic Risk Scores for Subtyping of Schizophrenia

Table 2

Symptom count changes between the baseline and the end of Phase I trial.

All subjectsClass IClass IIClass IIIClass IVClass V

Total symptom
Mean Diff4.175.473.901.124.893.41
95% CI2.59-5.752.76-8.190.78-7.03−3.34-5.58−0.12-9.90−0.32-7.14
5.173.982.483.181.971.82
43517181564479
3.50E-071.02E-040.01510.61600.05570.0725

Positive symptom
Mean Diff1.181.261.020.821.601.20
95% CI0.63-1.730.31-2.220.00-2.05−0.69-2.34−0.22-3.42−0.10-2.50
4.242.612.001.091.771.83
43517181564479
2.78E-059.90E-030.04920.28010.08390.0707

Negative symptom
Mean Diff0.931.360.65−0.632.180.73
95% CI0.39-1.480.47-2.25−0.54-1.83−2.32-1.050.53-3.82−0.49-1.94
3.383.031.08−0.752.651.19
43517181564479
7.94E-042.81E-030.28170.45560.01110.2382

Mean Diff: mean difference between the baseline and at the end of Phase I trial; 95% CI: 95% confidence interval; t: test value; df: degree of freedom; values ≤0.05 were highlighted by bold.