Schizophrenia Research and Treatment / 2020 / Article / Tab 5 / Research Article
Polygenic Risk Scores for Subtyping of Schizophrenia Table 5 A summary of subtypes classified by partially shared liability between schizophrenia and comorbid traits.
Class # subjects (%) Symptom improvement Cognitive function Laboratory test Other clinical features Class I 181 (39.3%) Total symptom ↓ Positive ↓ Negative ↓ VIGILANCE ↑ PROCESSING SPEED ↑ MEMORY ↑ REASONING ↑ HDL ↓ Reference Class II 94 (18.6%) Total symptom ↓ Positive ↓ PROCESSING SPEED ↑ Bilirubin ↓ Uric acid ↓ Lower baseline negative symptoms, lower bilirubin and uric acid, more likely to use tobacco product Class III 64 (12.9%) — VIGILANCE ↑ Phosphorus ↑ Class IV 53 (10.1%) Negative ↓ VIGILANCE ↑ PROCESSING SPEED ↑ MEMORY ↑ REASONING ↑ Lymphocyte ↓ Neutrophils ↑ More likely to have a family history and an older age when first prescribed antipsychotic medicine, less likely to discontinue medication due to the lack of effects Class V 90 (18.1%) — VIGILANCE ↑ PROCESSING SPEED ↑ HDL ↑ Calcium ↑ Phosphorus ↑ Prolactin ↑