Research Article

Polygenic Risk Scores for Subtyping of Schizophrenia

Table 5

A summary of subtypes classified by partially shared liability between schizophrenia and comorbid traits.

Class# subjects (%)Symptom improvementCognitive functionLaboratory testOther clinical features

Class I181 (39.3%)Total symptom ↓
Positive ↓
Negative ↓
VIGILANCE ↑
PROCESSING SPEED ↑
MEMORY ↑
REASONING ↑
HDL ↓Reference

Class II94 (18.6%)Total symptom ↓
Positive ↓
PROCESSING SPEED ↑Bilirubin ↓
Uric acid ↓
Lower baseline negative symptoms, lower bilirubin and uric acid, more likely to use tobacco product

Class III64 (12.9%)VIGILANCE ↑Phosphorus ↑

Class IV53 (10.1%)Negative ↓VIGILANCE ↑
PROCESSING SPEED ↑
MEMORY ↑
REASONING ↑
Lymphocyte ↓
Neutrophils ↑
More likely to have a family history and an older age when first prescribed antipsychotic medicine, less likely to discontinue medication due to the lack of effects

Class V90 (18.1%)VIGILANCE ↑
PROCESSING SPEED ↑
HDL ↑
Calcium ↑
Phosphorus ↑
Prolactin ↑