Research Article

Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: A Cautionary Report

Figure 4

Double label immunohistochemistry shows close association between glial fibrillary acidic protein (GFAP) and autofluorescence along the injector needle track in the striatum, 2 months after intranasal delivery of MSC-EGFPs. (a) Green autofluorescence along needle track. Inset, higher-magnification image from (a). (b) GFAP (red) expression is strong along the needle track. (c) Substantially less GFAP, and no green autofluorescence, is detected in the contralateral striatal hemisphere.
586586.fig.004a
(a)
586586.fig.004b
(b)
586586.fig.004c
(c)