Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: A Cautionary Report
Figure 4
Double label immunohistochemistry shows close association between glial fibrillary acidic protein (GFAP) and autofluorescence along the injector needle track in the striatum, 2 months after intranasal delivery of MSC-EGFPs. (a) Green autofluorescence along needle track. Inset, higher-magnification image from (a). (b) GFAP (red) expression is strong along the needle track. (c) Substantially less GFAP, and no green autofluorescence, is detected in the contralateral striatal hemisphere.
